Journal of Pharmacovigilance

Daria Cipollone

Publications

• Review Article
  Adipokines and their Involvement as a Target of New Drugs
  Author(s): Tania Di Raimo, Gabriella Azzara, Mariangela Corsi, Daria Cipollone, Vincenza Rita Lo Vasco and Rita BusinaroTania Di Raimo, Gabriella Azzara, Mariangela Corsi, Daria Cipollone, Vincenza Rita Lo Vasco and Rita Businaro
  
  Globesity is referred to a global epidemic of obesity, affecting millions of individuals. Molecules released by the enlarged adipose tissue, most of which are pro-inflammatory, have been named adipokines. The present review deals with function, molecular targets and the potential clinical relevance of adipokines. Currently, more than 600 adipokines have been identified, many of them, including leptin, visfatin, resistin as well as Retinol Binding Protein4 may serve as informative markers for metabolic and cardiovascular diseases and play important roles in glucose homeostasis, insulin sensitivity as well as metabolic regulation of energy expenditure. Adiponectin on the contrary exerts anti-inflammatory and insulin sensitizing activity. Adiponectin has additional anti-atherogenic effects and low adiponectin serum concentrations are associated with increased.. View More»
  DOI: 10.4172/2329-6887.1000166

  Abstract PDF