Cynthia W. Tuthill

Cynthia W. Tuthill
SciClone Pharmaceuticals Inc.,
950 Tower Lane, Suite 900, Foster City, CA 94404
Tanzania

Publications
  • Review Article
    Thymosin Apha 1–A Peptide Immune Modulator with a Broad Range of Clinical Applications
    Author(s): Cynthia W. Tuthill and Robert S. KingCynthia W. Tuthill and Robert S. King

    Objectives: To investigate the pharmacokinetics of Carbamazepine (CBZ) in rats during growth hormone treatment. Methods: Recombinant Human Growth Hormone (rhGH) was injected subcutaneously at a daily dose of 0.1 mg/ kg, 2 mg/kg, or phosphate buffered saline (control) for 5 days in male Sprague-Dawley rats. On day 6, a dose of 25 mg/kg of CBZ was injected intravenously via a jugular vein cannula into the rat. Growth rate were compared between treatment groups. The pharmacokinetics of CBZ was determined from its concentrations in rats’ blood and urinary samples. Results: Over the 5-day treatment period, growth rate were greater than control for the 2 mg/kg rhGH dosed group. The volume of distribution (Vss) was significantly (p<0.05) decreased in the high dosed rhGH rats compared to the control group. Total body clearance (CL) in the 2 mg/kg rhGH group was also significa.. View More»
    DOI: 10.4172/2161-1459.1000133

    Abstract PDF