Journal of Bioequivalence & Bioavailability

Cunningham G

Publications

• Research Article
  Non-Invasive Nasal Hydromorphone with High Bioavailability for Rapid Onset and Non-Dissociative Acute Pain Control: A Feasibility Study
  Author(s): Cunningham G and Maggio ETCunningham G and Maggio ET
  
  Aim: To test the hypothesis that intranasal hydromorphone could mimic IV administration parameters for use in acute pain situations such as battle field injury, EMS first response and breakthrough cancer pain. Methods: A single healthy volunteer was recruited to a monocentric, open label, randomized, four-way crossover pharmacokinetic study, with 7 days washout period between treatments (more than 70 times the terminal elimination half-life). The use of a single subject minimized the effect of person to person variability in metabolism. For small molecule drugs (i.e., MW<1,000 Daltons) nasal bioavailability in the presence of alkylsaccharide absorption enhancers is predominantly a function of molecular weight and is expected to be high. Unexpected impediments to nasal delivery are likely due to local mucosal irritation or vasoconstriction, w.. View More»
  DOI: 10.4172/jbb.1000369

  Abstract PDF