Journal of Clinical & Experimental Pharmacology

Coelho PMZ

Publications

• Research Article
  In vivo and In vitro of Arctiin Schistosomicidal Activity
  Author(s): Saco LC, Dias MM, Zaquine PM, Gusmão MAN, Emídio NB, Marconato DG, Nascimento JWL, Moraes JD, Pinto PLS, Coelho PMZ, Vasconcelos EG, Filho AADS and Faria-Pinto PDSaco LC, Dias MM, Zaquine PM, Gusmão MAN, Emídio NB, Marconato DG, Nascimento JWL, Moraes JD, Pinto PLS, Coelho PMZ, Vasconcelos EG, Filho AADS and Faria-Pinto PD
  
  Human schistosomiasis, caused by trematode worms of the genus Schistosoma, is one of the most significant neglected tropical diseases, affecting more 200 million individuals worldwide and praziquantel is the only available drug to treat this neglected disease. Arctiin is a lignan obtained from Arctium lappa (Asteraceae) with antiinflammatory and antiproliferative activities. Our purpose was to investigate the in vitro and in vivo schistosomicidal activities of arctiin in mice infected with S. mansoni. Arctiin (200 and 100 μM) caused mortality, tegumental alterations, and reduction of motor activity of adult worms of S. mansoni in culture. Oral administration of a single dose of arctiin (25 mg/kg) on day 45 of infection did not reduce worm burden or cause any alteration in the analyzed parameters when compared to infected untreated mice. On the other hand, intraperitoneal treatment .. View More»
  DOI: 10.4172/2161-1459.1000224

  Abstract PDF