Chojnowski Jacek
Poland
Research Article
Angiotensinogen Gene M235T and T174M Polymorphisms in Patients with Morbid Obesity and Type 2 Diabetes Mellitus
Author(s): Pacholczyk Marta, Ferenc Tomasz, Kowalski Jan, Adamczyk Przemysław, Chojnowski Jacek and Ponikowska IrenaPacholczyk Marta, Ferenc Tomasz, Kowalski Jan, Adamczyk Przemysław, Chojnowski Jacek and Ponikowska Irena
Background: Angiotensinogen and its cleaved form - angiotensin II are important regulators of adipose tissue metabolism and they may affect adipogenesis. Aim: We studied the correlation between M235T and T174M polymorphisms of angiotensinogen (AGT) gene and morbid obesity and their association with Type 2 Diabetes Mellitus (T2DM). We also investigated the role of haplotypes formed by these polymorphisms in the risk for extreme obesity and obesity- associated T2DM.
Material and methods: The study included 335 morbidly obese patients (study groups) and 230 subjects without obesity (control group). The molecular analysis was performed using Polymerase Chain Reaction (PCR) and PCR-restriction fragment length polymorphism technique.
Results: Distribution of the genotype for AGT M235T polymorp.. View More»
