Journal of Data Mining in Genomics & Proteomics

Journal of Data Mining in Genomics & Proteomics
Open Access

ISSN: 2153-0602

Chitlange NR

Chitlange NR


  • Research Article
    Microbial Proteomics Approach for Sensitive Quantitative Predictions of MHC Binding Peptide from Taenia Ovis
    Author(s): Virendra Gomase and Chitlange NRVirendra Gomase and Chitlange NR

    Taenia ovis is a tapeworm parasite with the adult stage of the parasite found in the intestines of dogs, while the intermediate or larval stage is found in the muscles of sheep, causes sheep measles. Peptide fragments of antigen protein can be used to select nonamers for use in rational vaccine design, and to increase the understanding of roles of the immune system in infectious diseases. Analysis shows MHC class II binding peptides of antigen protein from Taenia ovis are important determinants for protection of host from parasitic infection. In this assay, we used PSSM and SVM algorithms for antigen design and predicted the binding affinity of antigen protein having 254 amino acids, which shows 246 nonamers. Binding ability prediction of antigen peptides to Major Histocompatibility Complex (MHC) class I & II molecules is important in vaccine development against sheep measles... Read More»
    DOI: 10.4172/2153-0602.1000121

    Abstract PDF

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