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Chaili Siyang
Chaili Siyang
Tanzania
Publications
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Review Article
A Comparison of Management Strategies and Treatment Results for Neovascular Age-Related Macular Degeneration with a Focus on the Treat-Extend-Stop Protocol
Author(s): Chaili Siyang and Adrean Sean DChaili Siyang and Adrean Sean D
Neovascular Age-Related Macular Degeneration (nAMD) is a leading cause of blindness, but the management has been revolutionized by anti-vascular endothelial growth factor (anti-VEGF) agents. Three main treatment strategies have been developed to manage nAMD. The first method is fixed interval dosing, a mainstay of randomized clinical trials (RCT), where patients receive treatments on a monthly or bimonthly interval based on the anti-VEGF agent. Shortly thereafter, the pro-re-nata (PRN) method was introduced, where patients were treated as needed based on OCT status, usually preceded by three loading doses. Another method developed was the TreatAnd-Extend regimen (TAE). Patients are treated until a dry macula is obtained and then the time interval between injections is gradually increased, usually by one to two-week intervals. A variation of the TAE protocol, termed TreatExtend-Stop (T.. View More»