Byoung Seok Moon
Republic of Korea
Research Article
Mixture of Ethanol Extract of Grape Pomade and Omija Fruit Prevents Hyperglycemia and Alleviates Oxidative Stress in Mice Fed an Obesogenic Diet
Author(s): Su-Jung Cho, Un Ju Jung, Hye-Jin Kim, Ye Jin Kim, Youngji Han, Byoung Seok Moon, Yong Bok Park and Myoung-Sook ChoiSu-Jung Cho, Un Ju Jung, Hye-Jin Kim, Ye Jin Kim, Youngji Han, Byoung Seok Moon, Yong Bok Park and Myoung-Sook Choi
Background: A high-fat diet (HFD) is thought to be one of the main environmental factors for obesity in which oxidative stress is an important pathogenic mechanism of obesity-associated metabolic syndrome including diabetes. Polyphenol-rich food plants are known to improve obesity-related diseases. The aim of this study was to investigate the effects of grape pomace (GP) and GP plus omija fruit (GPOF) on hyperglycemia and oxidative stress in diet-induced obese (DIO) mice. Methods: Male C57BL/6J mice were fed an HFD with GP (0.5%, w/w) or GPOF (0.5% GP plus 0.05% omija fruit, w/w) for 12 weeks. One gram of GP contains 0.26 mg of total flavonoid and 0.475 mg of total polyphenol, while 1 g of GPOF contains 0.2635 mg of total flavonoid and 0.491 mg of total polyphenol. Results: GP and GPOF significantly lowered fasting blood glucose level and insulin/glucagon ratio compar.. View More»
