Brock B

Brock B
Rostock University, Medical Centre,
Schillingallee 35, 18057 Rostock
Germany

Publications
  • Short Communication
    O-Toluidine in Breath-Non-Invasive Prilocaine Monitoring
    Author(s): Brock B, Kamysek S, Trefz P, Fuchs P, Timm U, Miekisch W and Schubert JKBrock B, Kamysek S, Trefz P, Fuchs P, Timm U, Miekisch W and Schubert JK

    The generation of methaemoglobin is a rare but potential life-threatening side effect in the use of the local anaesthetic prilocaine. It is currently only possible to ensure the diagnosis by means of blood tests. Rapid noninvasive diagnosis is desirable, especially for risk patients. Using a pig model, we induced methaemoglobinemia via application of dimethyl aminophenol and prilocaine (setup I) or natrium nitrite and prilocaine (setup II). Continuous real time breath gas monitoring was performed by proton transfer reaction-time-of-flight-mass spectrometry (PTR-TOF-MS) for non-invasive determination of volatile organic compounds (VOCs). O-Toluidine, the main metabolite of prilocaine, could be detected in alveolar breath gas by means of PTR-TOFMS and was confirmed by NTME-GC-MS (needle trap micro-extraction gas chromatography-mass spectrometry). The administration o.. View More»
    DOI: 10.4172/2161-1459.1000242

    Abstract PDF