Journal of Blood Disorders & Transfusion

Bremansu Osa-Andrews

Publications

• Research Article
  Role of Circulating Endothelial Progenitor Cells in Micro VascularDamage in Sickle Cell Patients
  Author(s): Bremansu Osa-Andrews, Henry Asare-Anane, Sylvester Yaw Oppong, Alexander Kwadwo Nyarko, George Kpentey, John Tetteh and Ben GyanBremansu Osa-Andrews, Henry Asare-Anane, Sylvester Yaw Oppong, Alexander Kwadwo Nyarko, George Kpentey, John Tetteh and Ben Gyan
  
  The vascular wall participates in the pathogenesis of sickle cell disease (SCD). Circulating Endothelial progenitor cells (cEPCs) also play a key role in the vascular pathology of SCD, including the painful crisis. In previous investigations, reduced levels of cEPCs were found in conditions in which vascular injury is implicated such as myocardial infarction. The aim of this research is to study the role of cEPCs in the vascular pathology of SCD. cEPCs were enumerated using flow cytometry with the Flow Activated Cell Sorting machine (FACS). To differentiate the various genotypes-SS, SC, AS, AC and AA, Hb Electrophoresis was employed. Results showed that the median % cEPCs (CD34+/VEGF-2+) was lower in patients with SCD [0.555(0.4, 0.765)] than in healthy controls [(1.08(0.87, 1.39) (p=0.001)]. Patients in crisis had a higher cEPCs (0.65+0.39) than those in steady state (0.59+0.28) (p=0.. View More»
  DOI: 10.4172/2155-9864.1000389

  Abstract PDF