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Bader S
Bader S
Germany
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Research Article
Cerium Oxide Nanoparticles as Novel Tool in Glioma Treatment: An In vitro Study
Author(s): Sack-Zschauer M, Bader S and Brenneisen PSack-Zschauer M, Bader S and Brenneisen P
The interaction between cancer cells and the stromal microenvironment is an important aspect in tumor progression and reflects a big challenge especially in context of an efficient treatment of brain tumors such as gliomas. An intensive crosstalk between glioma cells and stromal cells such as endothelial cells inter alia being part of the blood-brain barrier (BBB) often results in the occurrence of a relapse and poor prognosis. A complete resection of gliomas which are characterized by a high proliferation rate and invasiveness as well as extensive vascularization is not possible until yet and a post-operative care with existing therapies is crucial and often not as successful as expected. In that context, redox-active nanoparticles such as cerium oxide nanoparticles (CNP) are a promising tool and may solve some treatment problems closely associated with brain tumors. In this study, C.. View More»
DOI: 10.4172/2157-7439.1000474