Arsalan Azimi

Arsalan Azimi

Shiraz
West Indies

Publications
  • Hypothesis
    Pentoxifylline Explores New Horizons in Treatment of Hashimoto Thyroiditis
    Author(s): Arsalan AzimiArsalan Azimi

    Hashimoto Thyroiditis is an autoimmune disease and the most common cause of hypothyroidism in developed countries. As the disease initiates unusual thyroidal antigens are exposed to the immune system. The immune system sensitizes to those antigens and creates a cell mediated autoimmune response against thyroid gland. Inflammatory cells infiltrate within thyroid follicles and destruct the follicles by inflicting oxidative stress and inducing apoptosis. The inflammatory process also reduces sensitivity of thyrocytes to Thyroid Stimulating Hormone (TSH). As the disease progresses and the follicles degrade, fibrotic tissue replaces the follicles until the whole gland becomes fibrotic. Pentoxiflline could inhibit autoimmune destruction of thyrocytes, suppress cell mediated immune response against thyroid, decrease oxidative damage to thyrocytes, increase sensit.. View More»
    DOI: 10.4172/0974-8369.1000293

    Abstract PDF