Journal of Blood Disorders & Transfusion

Journal of Blood Disorders & Transfusion
Open Access

ISSN: 2155-9864


Arsalan Azimi

Arsalan Azimi
Histomorphometry and Stereology Research Centre,
West Indies

  • Short Communication
    Pentoxifylline Lifts the Burden of Preeclampsia
    Author(s): Arsalan AzimiArsalan Azimi

    Worldwide, Preeclampsia is the leading cause of maternal morbidity and perinatal mortality and it initiates as inappropriate immune response to trophoblastic invasion impairs placentation and placental circulation followed by generation of superoxide anions as well as anti-angiogenic factors and this series of events result in impairment of maternal/placental endothelial function, maternal hypertension, kidney injury, proteinuria and thromboembolic events. Renal loss of anti-coagulant proteins and subsequent hyper-coagulable state along with endothelial dysfunction accelerates progression of the disease toward eclampsia. Pentoxifylline, could hypothetically modify pathophysiological mechanisms of preeclampsia including impaired immune response, placentation, endothelial function and coagulation, so it could explore new horizons in treatment of preeclampsia... Read More»
    DOI: 10.4172/2155-9864.1000332

    Abstract PDF

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