Anoosha Jonnalagadda
Krupanidhi College of Pharmacy,
No.12/1, Chikkabellandur, Carmelram Road and Post, Varthur Hobli, Bangalore 560035, Karnataka
India
Research Article
Combined Effect of Syzygium cumini Seed Kernel Extract with Oral Hypoglycemics in Diabetes Induced Increase in Susceptability to Ulcerogenic Stimuli
Author(s): Anoosha Jonnalagadda, Karthik K Maharaja and Prem Kumar NAnoosha Jonnalagadda, Karthik K Maharaja and Prem Kumar N
Diabetes has been reported to increase propensity to peptic ulceration through its effect both on offensive and defensive mucosal factors. Seeds of Syzygium cumini have been reported to have both antidiabetic as well as ulcer protective effects. The present study evaluated the antidiabetic effects of ethanolic extract of dried seed kernel of Syzygium cumini (200 mg/kg) and its comparative effect on gastric ulceration with standards Acarbose (5 mg/kg) an α-glucosidase inhibitor and natural standard Quercetin 50 mg/kg and 100 mg/kg. The study also investigated the combined effect of Syzygium cumini seed kernel extracts with oral hypoglycemic agents in diabetes induced ulcer. The development of diabetic ulcers was assessed biochemically. Diabetes was induced by high fat diet/low dose streptozotocin (35 mg/kg). The protective effects of Syzygium cumini in rats with type 2 diabetes m.. View More»
