Biology and Medicine

Anazoeze Jude Madu

Publications

• Review Article
  The Role of Lipids in Inflammation: Review of the Evolving Pathogenesis of Sickle Cell Disease
  Author(s): Anazoeze Jude Madu, Nada Abuknesha and Kebreab GhebremeskelAnazoeze Jude Madu, Nada Abuknesha and Kebreab Ghebremeskel
  
  The pathologic features of sickle cell disease had been known in the past to be as a result of red cell abnormality leading to vascular occlusion, haemolysis and consequent anaemia. Recent knowledge has revealed numerous pathogenetic pathways involving leukocytes, platelets and the vascular endothelium. Complex interactions between the inflammatory cytokines and the membrane lipids in sickle cell present several pathogenetic processes affecting disease severity. The mechanisms of membrane fluidity, aggregation, adhesion and inflammation are strongly associated with membrane lipid constitution. The omega -3 fatty acids via incorporation into the lipid membrane have been found to play a central role in suppressing inflammation in several disease processes. Variations in disease severity have been shown to correspond with levels of fatty acid desaturases invo.. View More»
  DOI: 10.4172/0974-8369.1000244

  Abstract PDF