Journal of Data Mining in Genomics & Proteomics

Amarpal Singh

Publications

• Research Article
  N-W Algorithm and ANFIS Modeling on Alignment Similarity of Triplex Capsid Protein of Human Herpes Simplex Virus
  Author(s): Vipan Kumar Sohpal, Apurba Dey and Amarpal SinghVipan Kumar Sohpal, Apurba Dey and Amarpal Singh
  
  Optimal sequence similarity of triplex capsid proteins of human herpes simplex virus (HHV) is a complex bioinformatics problem, which is controlled by alignment algorithms, substitution matrix, gap penalty and gap extension. A precise choice of mutation matrix is required to optimal the alignment similarity and appropriate computational approach required for similarity search. The present paper uses Adaptive Neuro-Fuzzy Inference System (ANFIS) approach to model and simulate the alignment similarity for PAM and Blosum substitution matrices. Mutation matrix and sequences of HHV-I and HHV-II were taken as model’s input parameters. The model is the combination of fuzzy inference, artificial neural network, and set of fuzzy rules has been developed directly from computational analysis using N-W algorithm. The proposed modeling approach is verified by comparing the expected results w.. View More»
  DOI: 10.4172/2153-0602.S3-001

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