Journal of Allergy & Therapy

Journal of Allergy & Therapy
Open Access

ISSN: 2155-6121

Alicia N Rizzo

Alicia N Rizzo


  • Review Article
    The Importance of Bronchial Epithelial Junction Integrity in Asthma
    Author(s): Hongbing Xiao, Alicia N Rizzo, Jessica Siegler and Weiguo ChenHongbing Xiao, Alicia N Rizzo, Jessica Siegler and Weiguo Chen

    Bronchial epithelial junctions provide not only a physical barrier, but also an immune barrier against the allergens of asthma. Epithelial junction integrity is closely related to the severity and progression of asthma. The bronchial epithelial barrier consists of tight junctions, adherens junctions, desmosomes, hemidesmosomes and gap junctions, all of which are potentially implicated in asthma pathophysiology. In tight junctions, claudins, occludens, ZO-1 and β-catenin expression have been shown to be decreased by asthma allergens, resulting tight junction disruption. Similarly, E-cadherin and α-catenin levels have also been reported to be dysregulated in response to asthma allergens, resulting in alterations in adherens junction structure. Asthma allergens also alter desmosome and hemidesmosome structure; however, no reports have shown that desmosome or hemidesmosome junc.. Read More»
    DOI: 10.4172/2155-6121.S11-003

    Abstract PDF

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