Alexander E Berezin
Consultant of Cardiology Unit, Internal Medicine Department, State Medical University 26, Mayakovsky av, Zaporozhye,
Ukraine
Research Article
The Development of Biological Molecular Sensing Techniques to detect Micro particles: Focus on Clinical Medicine Benefits
Author(s): Alexander E BerezinAlexander E Berezin
Microparticles (MPs) are defined a heterogeneous population of vesicles (diameter 100-1000 nm) that are released by cellular vesiculation and fission of the membrane of cells and play a pivotal role in various diseases including cardiovascular diseases, cancer, sepsis, eclampsia, autoimmune and metabolic states. Currently there is no standardization regarding analytical methods of MP detection. Conventional methods have crucial limitations regarding complicated assay and suffers from relatively low sensitivity and accuracy because of resolution problems occurring for the majority of commercially available flow cytometers. Alternatively, recently recognized as a method for quantification and sizing of biological nanoparticles surface plasmon resonance-based imaging microscopy (SPRi microscopy) might be significantly useful to resolve the majority problems a.. View More»
DOI:
10.4172/1948-5948.1000214