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Akmali M
Akmali M
Shiraz
West Indies
Publications
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Research Article
The Antianginal Agent Ranolazine Inhibits Mitochondrial β-Oxidation Pathway
Author(s): Khazraei H, Mirkhani H and Akmali MKhazraei H, Mirkhani H and Akmali M
Abstract Backgrounds: Ranolazine had two main functions: blocking cardiac late sodium channels and / or inhibition of 3- ketoacyl coenzyme A thiolase, an important enzyme in �-oxidation of fatty acids. Diabetic cardiomyopathy is a complication, defined as cardiac dysfunction without the involvement of epicardial vessels. In this study, the effect of ranolazine on fatty acid oxidation was investigated in diabetic rats induced by streptozotocin. Methods: After 8 weeks of diabetic induction, the effect of ranolazine on fatty acid oxidation rate was studied. Statistical data were analyzed using Mann-Whitney test. Results: The activity of �-oxidation enzymes were inhibited by ranolazine in the normal rat hearts significantly, while no significant inhibition was seen in diabetic ones. Conclusion: Our data suggest that the clinical efficacy of ranolazine in diabetic patients is associated with .. View More»
DOI: 10.4172/2161-1459.1000203