Ajiboye John Adebayo
Nigeria
Research Article
Stem Bark Extract from Alstonia boonei attenuates Cholesterol, Triglyceride and Oxidative Damage via Low Immunohistochemical Expression in Small Intestinal Tract of Male Rats
Author(s): Akintunde Jacob Kehinde, Ajiboye John Adebayo, Soyinka O Oluwadamilola and Adeyemi A ArinolaAkintunde Jacob Kehinde, Ajiboye John Adebayo, Soyinka O Oluwadamilola and Adeyemi A Arinola
Stem bark extract of Alstonia boonei (SBEAB) was reported to possess anti-lipidemia, anti-microbial, antiinflammatory and anti-hypercholesterolemia properties in folk lore medicine. The present study examined the effects of SBEAB on some key lipid profiles in diabetic induced rats. Biomarkers of lipid damage, histological and immunohistochemical method were used. The expression level of cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) were also determined. SBEAB administered orally at dose of 200 mg/kg for 14 days significantly lowered the levels of cholesterol, triglyceride and malondialdehyde induced by single intraperitoneal administration of streptozotoxin (STREP) (80 mg/kg) and preserved the integrity of intestinal villi. In addition, SBEAB reduced the STREP-induced elevated activity of CAT with concomitant repression of COX-2 and iNOS e.. View More»
