Journal of Clinical & Experimental Pharmacology

Ahmed A Abdelsameea

Publications

• Research Article
  Effects and Interactions of Ginger and Propranolol in Pre-Hepatic Portal Hypertensive Rats
  Author(s): Ahmed A Abdelsameea, Sohair S El-menshawy, Hepa F Pasha and Mahmoud W EmaraAhmed A Abdelsameea, Sohair S El-menshawy, Hepa F Pasha and Mahmoud W Emara
  
  Abstract Background and Aim: Portal hypertension (PHT) is a frequent sequel of liver fibrosis and cirrhosis. Propranolol is commonly used for lowering portal pressure and preventing variceal bleeding. The hepato-protective effect of ginger has been reported. The aim of this study is to assess the effects and interactions of ginger and propranolol in prehepatic PHT in male albino rats. Materials and Methods: Adult male albino rats were divided into 3 main groups. The first group: control rats. The second group: sham-operated rats and third group: pre-hepatic portal hypertensive rats induced by partial portal vein ligation (PPVL). The third group is subdivided into subgroup: untreated-PPVL group and subgroups 2-6 were treated with propranolol 75 mg/Kg; ginger 90 mg/kg; 180 mg/Kg; ginger 90 mg/kg plus propranolol 75 mg/kg, .. View More»
  DOI: 10.4172/2161-1459.1000179

  Abstract PDF