Journal of Clinical & Experimental Pharmacology

Ahmed A

Publications

• Research Article
  Synergistic Ameliorative Effects of Resveratrol with Leflunomide on Serum Levels of Inflammatory Biomarkers and Joint Damage in Rats with Adjuvant Arthritis
  Author(s): Ahmed A and Bader AAhmed A and Bader A
  
  Abstract Background: Rheumatoid arthritis (RA) is chronic irreversible inflammatory disorder and characterized by the thickening of synovial tissue with pannus formation and the destruction of joint structure; due to persistent overproduction of proinflammatory cytokines (TNF-α and IL-6), proinflammatory enzymes such as cyclooxygenase II (COX-2) and matrix metalloproteinases. Leflunomide, potent pyrimidine biosynthesis inhibitor, exhibiting anti-inflammatory and immunosuppressive actions and resveratrol is a potent antioxidant and anti-inflammatory agent; exerting potential antiarthritic effects and also can protect diverse tissue types as heart and colon in different experimental animal models. Objective: Evaluating outcomes of combinational use of both resveratrol and leflunomide on serum levels of proinflammatory biomarkers contributing to progression and sev.. View More»
  DOI: 10.4172/2161-1459.1000170

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