Hereditary Genetics: Current Research

Hereditary Genetics: Current Research
Open Access

ISSN: 2161-1041


Agnès Veyradier

Agnès Veyradier
Service d′Hématologie biologique Hôpital Antoine Béclère,
157 rue de la Porte-de-Trivaux, 92140 Clamart

  • Review Article
    ADAMTS, Thrombotic Thrombocytopenic Purpura and Pregnancy
    Author(s): Agnès Veyradier, Alain Stepanian and Paul CoppoAgnès Veyradier, Alain Stepanian and Paul Coppo

    Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA) which pathophysiology mainly relies on a severe deficiency (either acquired or inherited) of ADAMTS13, the specific von Willebrand factor (VWF) protease. TTP is characterized by a feminine predominance and pregnancy is a precipitating factor for TTP boots. Obstetrical TTP represents at least 20% of all TTP occurring in child-bearing age women. In this review, an analyze of the English-language literature from 1955 to 2011 found about 350 cases of obstetrical TTP including about 40 case-reports/-series with well documented ADAMTS13 investigation (32 inherited and 17 acquired TTP with severe ADAMTS13 deficiency). In the 32 patients with inherited TTP, the first pregnancy was systematically associated with a TTP boot, mostly occurring during the third trimester; curative plasma therapy (PT) allowed a .. Read More»
    DOI: 10.4172/2161-1041.S1-002

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