Journal of Microbial & Biochemical Technology

Journal of Microbial & Biochemical Technology
Open Access

ISSN: 1948-5948



Use the Best of MNPS-IHSP Nanoparticles with Coating of Ampicillin Antibiotic, as Bactericidal Properties

Mansour Binandeh*, Farokh Karimi, Sadegh Rostamnia

In this research, we have tried to maximize the potential of Fe3O4 magnetic nanoparticles coated by SiO2 and
immobilized with imidazoline hetropolymer (MNPS-IHSP) to stabilize and release the drug molecule called ampicillin
(amp). In this purpose, nanoparticles of 50 nm in size were investigated under a tool such as; FT-IR, SEM, EDX
detection and its structure in-vitro conditions. MNPS-IHSP nanoparticles is a specific and suitable nanocomposite
that it have a mission as well as stabilizing the amp in the presence of silica coating (electrostatic bonding), that it
called MNPS-IHSPA, and the results indicate a stabilization with a higher percentage of 85. It was beneficial to
the silica coating. This measurement was performed by a UV-V is spectrophotometer analysis. Ultimately, in-vitro
conditions, these magnetic nanoparticles that were migrating with ampicillin was tested on growing bacteria and
resulted in the bacterial killing, indicating the antibacterial properties of magnetic nanoparticles. Ultimately, the
project tells us that it can also be useful for destroying pathogenic bacteria living cells in vivo conditions.

Published Date: 2019-04-30; Received Date: 2019-03-07