Oral Health and Dental Management

Abstract

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms: Markers of Innate Immunity in Oral Infection in Children

Maya Rashkova, Andrey Kirov, Albena Todorova, Vanyo Mitev

Introduction: Innate immunity is activated with the participation of pattern recognition receptors (PRRs). Toll-like receptors (TLRs) are signal molecules essential for the cellular response to bacterial cell wall components. Aim: The aim of the study was to use gene identification of Toll-like receptors (TLR2 and TLR4) to investigate this marker of innate immunity in children with chronic inflammation oral diseases. Methods: Three groups of 30 children, one with a history of ear, nose and throat (ENT) infections, one with clinically healthy gingival and no history of ENT infections, and one with gingivitis and no history of ENT infections, were recruited. DNA samples were taken from the children