Carolina Amália Barcellos Silva, Alessandra Dutra da Silva, Maria Inês Meurer, Filipe Modolo, Liliane Janete Grando
Pemphigus Vulgaris is a chronic autoimmune mucocutaneous disease, in which oral lesions could be the first site observed, although skin and other mucous membranes may also be affected. Clinically, the lesions are characterized by many painful blisters that rapidly rupture resulting in erosions and/or multiple ulcers in the oral mucosa and skin, which can be difficult to differentiate from other vesiculobullous or ulcerative disorders. Many patients may be misdiagnosed and improperly treated for a long time. It is considered a serious chronic disease and its treatment represents a real therapeutic challenge. We present 8 case reports of pemphigus vulgaris, in which a thorough evaluation was made, recording patient age and sex, the location and extent of the lesions, their signs, symptoms and treatment, with emphasis on the difficulty of the diagnosis and clinical management of these patients.