Journal of Clinical & Experimental Pharmacology

Abstract

^99mtc-Depreotide And ^99mtc-EDDA/HYNIC-Tyr3-Octreotide Somatostatin Receptor Scintigraphy in Evaluation of Radiologically Indeterminate Solitary Pulmonary Nodules

Beata E. Chrapko, Anna Nocun, Pawel Rybojad, Marek Sawicki, Ewa Poniatowicz-Frasunek and Elzbieta Czekajska–Chehab

The aim of our study was to assess somatostatin receptor scintigraphy (SRS) in evaluation of solitary pulmonary nodules (SPNs). 93 patients with SPNs underwent SRS single photon emission tomography (SPECT) performed with use of one of two somatostatin analogues: 99m Tc-depreotide (49 patients) and 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide (44 patients). 99m Tc-depreotide uptake was true positive (TP) in 37/38 malignant SPNs, and true negative (TN) in 10/11 patients, one false-negative (FN) result and one false-positive (FP) result; the sensitivity, specificity and diagnostic accuracy was 97%, 91% and 96% respectively.

In 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide SRS there were 12 of 20 TP results, 21 of 24 TN results, 8 of 20 were FN and 3 of 24 was FP, resulting in a sensitivity, specificity and diagnostic accuracy of 60%, 88% and 75% respectively. Conclusions : 99m Tc-depreotide SRS in evaluation of SPNs can be recommended as alternative method of diagnosis, while 99m Tc-EDDA/HYNIC-Tyr 3 -octreotide SRS is less effective.