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Abstract

Study on screening Vietnamese herbs with antiviral activity to create products to support treatment of some diseases caused by RNA-virus

Quang Huan Le*, The Quan Nguyen, Hoang Minh Duc, Thi Tam Quyen Doan, Thi Huyen Trang Chu, Thu Thao Dao and Thi Thanh Huong Ha

Using information technology and traditional oriental medicine research, we have screened 5 Vietnamese herbs that contain active ingredients with antiviral effects. Andrographispaniculata, Syzygiumaromaum, Zingiber officinale Rose, Houttuyniacordata, Glycyrrhizauralensis Fisch. The active ingredients in herbs are extracted by ultrasound in a water-ethanol solvent system and made in the form of a nanometer complex, then mixed in specified proportions to form the product. The product was evaluated cytotoxicity by MTT (3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide) assay and evaluated the growth inhibition effect of H5N1 virus. Result: The complex of active ingredients in the composition has the nanometer size, the main size is 443 nm, the zeta potential is -11.9 mV. The inhibitory activity of the H5N1 virus was dose-dependent, and a concentration of 3 mg/mL completely inhibited the growth of the H5N1 virus in the erythrocyte agglutination test.

Published Date: 2021-03-23; Received Date: 2021-02-13