Journal of Diabetes & Metabolism

Journal of Diabetes & Metabolism
Open Access

ISSN: 2155-6156



Role of the ENPP1 K121Q Polymorphism and Susceptibility to Type 2 Diabetes in North Indian Punjabi Population

Badaruddoza, Basanti Barna, Kawaljit Matharoo and Bhanwer AJS

In many worldwide populations, the K121Q variant of ENPP1 gene are associated with increased risk of type 2 diabetes mellitus (T2DM). The objective of the present study was to investigate the association of K121Q variant of ENPP1 gene with T2DM in North Indian Punjabi populations. A total of 500 participants consisting 250 T2DM patients and 250 healthy unrelated subjects were recruited for this study. The PCR-RFLP method was used for genotyping of K121Q polymorphism. The minor allele Q was found to be significantly associated with increased risk of T2DM (OR: 1.44, 95% CI: 1.06-1.94, p=0.015). A significant difference in QQ genotype was observed between T2DM patients and control groups (OR: 2.04, 95% CI: 1.04-3.98, p=0.033). It is also observed that co-dominant model would be best fit to predict the susceptible gene effect (OR: 1.36, 95% CI: 1.04-1.80, p=0.026). This study confirmed the association of ENPP1 polymorphism with increased risk of T2DM.