Modern Chemistry & Applications

Abstract

Role of Krebs Cycle in the Mechanism of Stability Internal Medium and Internal Energy in an Organism in Norm and in Mechanisms of Cancer Pathology

Ponizovskiy MR

The mechanisms stability of both an open non equilibrium non linear thermodynamic system of a human organism and the open non equilibrium non linear thermodynamic system of an organism’s cells were considered via study the mechanism operation of Krebs tricarboxylic acid or citric acid cycle. Just study mechanism operation of Krebs tricarboxylic acid cycle in open thermodynamic systems of both an organism and an organism’s cells gives possibility to describe the biochemical and biophysical mechanisms interactions between anabolic processes and catabolic processes considering mutual influences between anaerobic catabolic processes and aerobic catabolic processes. Also there was explained the role of Krebs cycle in biochemical and biophysical mechanisms of stability open non equilibrium nonlinear thermodynamic system of a human organism and an organism’s cells. Besides there were described the influences of Krebs cycle property on mechanisms operation of cellular capacitors contributing to maintenance stability Internal Energy both an organism and cells of an organism due to remote cellular reactions via cellular capacitors operations preceding contacts cellular reactions which leads to immune reaction on strange objects into an organism saving stability Internal Energy and Internal Medium as an organism as well as cells of an organism. Moreover there were described the mechanism of partial destruction Krebs acids cycles leading to partial violation of interactions between catabolic anaerobic processes and catabolic aerobic processes due to partial inhibition catabolic processes in Warburg effect mechanism of cancer metabolism. Also there was described the mechanisms of the offered method prevention supplementary metastasis in processes of up-to-date chemotherapy and was described practical application of this method treatment on the cancer disease patient.