Venkatesh K Raman, Paola Chrysostomou and Vasilios Papademetriou
Hypertensionis a global health epidemic, affecting up to one-third of adults. Despite a plethora of pharmacologic agents that lower blood pressure and mitigate end-organ damage as well as cardiovascularevents, a significant percentage of patients fail to achieve target reduction. A subset of these patients is considered to have resistant hypertension with markedly elevated blood pressure despite treatment using at least three agents, including a diuretic. With significant excess risk, additional treatment options for these patients remain an unmet need.
