The effect of different weather conditions on fruit quality of ‘Pisana’ apricot cultivar (Prunus armeniaca L.) was evaluated over seven consecutive harvesting seasons in central Italy. The main physical-chemical traits, total antioxidant capacity and total phenols of fresh apricots at ready-to-eat were studied. The fruit quality showed a high variability in relation to the climatic conditions, particularly due to the summer rainfall. The most influenced quality parameters were TSS, TA and antioxidant levels: under wet seasons a huge reduction was observed, while strong drought conditions increased these chemical compounds. To improve fruit quality, ‘Pisana’ cultivar benefits of environmental conditions typical of temperate and semi-temperate regions, where water is usually limited.