Journal of Data Mining in Genomics & Proteomics

Abstract

Progress and Clinical Applications in Proteomics

Rie Karasawa

The innovative “omics” technologies such as genomics, transcriptomics, proteomics, and metabolomics have greatly contributed to biomedical discovery and advances. A single gene can engender multiple protein products as a consequence of modulation in the processes of protein production from DNA such as transcription, processing and translation. In addition, protein modifications such as phosphorylation, dephosphorylation, glycosylation, acetylation, sulfation, hydroxylation, carboxymethylation and prenylation occur in vivo. Furthermore, it has been reported that the correlation between mRNA and protein levels was not sufficient to predict protein expression levels from mRNA information