The national Centre for biotechnological information (NCBI) is part of the United States of America. The role in research and education specific to fundamental molecular and genetic processes that control health and disease is done by National Library of Medicine (NLM) NCBI. Introduction to NCBI databases and maps help researchers select tool that may help in finding sequences. A particular helpful feature is science primer, which provides an easy to read introduction to many science topics relevant to NCBI resources like Bio informatics, Molecular modelling, Genome mapping and Molecular genetics. An effort to sequence entire genome adds to the number of protein sequences by a factor of two each year, the gap between sequence and structural information stored in Public databases is growing rapidly. In contrast to sequencing techniques, an experimental method for structure determination takes lot of time and limited in their application. Therefore it’s not able to keep pace with the flood of newly characterised gene products. The growth of practical methods for predicting protein structure from sequence is therefore of significant importance in field of biology.