Abstract

Pleiotropy of Presenilins

Airong Li and Rudolph E Tanzi

Pleiotropy genes affect multiple and apparently unrelated phenotypes. Here we describe pleiotropy gene
presenilins, mutations in which have been detected in three genetically heterogeneous diseases: early-onset familial Alzheimer’s disease, familial or sporadic dilated cardiomyopathy, and familial hidradenitis suppurativa.