Journal of Bioequivalence & Bioavailability

Abstract

Metabolic Syndrome - A Bomb with Delayed Reaction

Genel S, Emanuela F and Lucia SM

Premise: According to the International Diabetes Federation (IDF) consensus worldwide 2013 the metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. It is known that about 20-25% of the world population has metabolic syndrome. The risk of dying through complications such as heart attack or stroke is two to three times higher than the general population. Platinum standard definition (IDF) proposed for including metabolic syndrome in addition to other measurements determination of pro-inflammatory status. Objectives: Identifying inflamation and its severity using inflamatory markers: C-reactive protein fibrinogen and leukocytes. Assesment of these markers considering the diversity of metabolic syndrome elements. Material and method: We performed a study that enrolled 152 patients registered to a family physician and diagnosed with metabolic syndrome. The subjects included in study were divided in two groups: group A-78 subjects diagnosed with metabolic syndrome that was defined by 3 elements: abdominal obesity+arterial hypertension+diabetes mellitus; group B-74 patients diagnosed with metabolic syndrome based on 5 elements: abdominal obesity+arterial hypertension+diabetes mellitus+decreased high density lipoprotein+increased triglycerides. We also established a control group-30 healthy people to compare inflammatory markers values. Results: We observed increased values of CRP fibrinogen and leukocytes for group B in comparison to group A: 0.9±0.8 mg/dl vs 0.79 ± 0.8 mg/dl (p=0.02, significantly statistic)Fibrinogen increased in group B significantly in comparison to group A (442,35 versus 365,8 p=0,0006. Leukocytes level was less responsive in patients with metabolic syndrome; leukocytes value was higher for group B, but not significantly statistic. Conclusions: Inflammation in patients with metabolic syndrome depends on the number and association of elements that define this entity, being more accentuated for subjects who associate more elements.