Journal of Thrombosis and Circulation: Open Access

Abstract

Plasma DNA and Neutrophil Extracellular Traps (NET): A Novel Biomarker in Lower Limb Venous Thrombosis

Indrani Sen

The traditional teaching of the pathophysiology of thrombosis centers around platelets and the coagulation cascade. However, the role of neutrophils in the thrombotic process is an area of recent interest. This role of neutrophils in this novel process of cell death and formation of neutrophil extracellular traps (NETs) has been linked to multiple disease processes like vasculitis, sepsis, cancer and haematological disorders in which a diagnostic and therapeutic role are being rapidly elucidated. Deep vein thrombosis and pulmonary embolism is a major worldwide health concern with significant mortality and morbidity. The role of NETs in lower limb thrombosis is under study. In this review, we review the need for a good biomarker in DVT, the role of NETs in thrombosis focussing on lower limb venous thrombosis.