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Abstract
Pharmaceutical Technologies for Enhancing Oral Bioavailability of Poorly Soluble Drugs
The oral bioavailability of BCS (biopharmaceutics clas- sification system) class II drugs with poor solubility and reasonable permeability is limited by the drug dissolution step from drug products. Though prodrug approach is an exciting way of improving the oral bioavailability, it re- quires extensive studies to establish the safety profile of prodrugs in humans. In view of the increasing market share of oral drug products, a variety of technologies are devel- oped to enhance the oral bioavailability of poorly soluble drugs using the excipients with approved or GRAS (gener- ally regarded as safe) status. The present review describes the main technologies such as micronization, nanosizing, crystal engineering, solid dispersions, cyclodextrins, solid lipid nanoparticles and other colloidal drug delivery sys- tems with a few relevant research reports.