Pharmaceutica Analytica Acta

Abstract

Partial Least Squares and Continuous Wavelet Transformation in Simultaneous Spectrophotometric Determination of Amlodipin and Atorvastatine

Masoud Shariati-Rad, Mohsen Irandoust, Tayyebeh Amini and Farhad Ahmadi

A simple spectrophotometric method for simultaneous determination of amlodipin and atorvastatine in pharmaceutical preparation is proposed based on the partial least squares and continuous wavelet transformation. The resulted partial least squares models were employed for prediction of the two drugs in two brands of combined pharmaceutical preparations which resulted in percent recoveries of 100.7 and 101.4 for amlodipin and 98.6 and 100.1 for atorvastatine. In the best conditions, the results of percent recoveries by continuous wavelet transformation zero-crossing were: 110.3 and 109.0 for amlodipin and 99.7 and 99.7 for atorvastatine for brand 1 and 2, respectively.