Abstract

Novel Therapy with Hybrid Liposomes for Orthotopic Graft Mouse Models of Glioblastoma

Keiji Kuwabara, Hideaki Ichihara and Yoko Matsumoto*

Hybrid Liposomes (HL25) composed of 90 mol% L-a-Dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(25) dodecyl ethers (C12(EO)25) were found to fuse and accumulate in the cell membranes of human brain tumor, glioblastoma, (U-87MG) cells and inhibit their growth. HL25 induced apoptosis in U-87MG cells via the release of AIF under a caspase-independent pathway. HL25 inhibited tumor enlargement in orthotopic graft mouse models of glioblastoma after crossing the blood-brain barrier.

Published Date: 2021-03-01; Received Date: 2021-02-08