Virus infection, inflammation and genetic factors play important roles in the pathogenesis of diabetes mellitus. The role of chronic inflammation in the pathogenesis of diabetes mellitus and associated complications is increasingly recognized. In all classes of immunoglobulin, the light chains comprise 1 of 2 subtypes, known as kappa and lambda. Immunoglobulin light chains are synthesized in excess during the generation and assembly of complete immunoglobulins, and can be found in the circulation under normal physiological conditions, whereas during inflammatory conditions, greatly enhanced concentrations are found in various body fluids. Nuclei factor kappa B (NF-kB), originally identified as a family of transcription factors that bind the enhancer of the immunoglobulin kappa light chain gene of B cells, plays critical roles in the development, survival, and activation of B cells, and its activation is a critical mechanism of the inflammatory cascade in the development of diabetes.
Published Date: 2021-05-24; Received Date: 2021-05-03