Akintunde JK and Oboh G
The rate at which diabetes mellitus and hypertension affect people in the whole world is tremendously increasing due to continuous occupational exposure to complex mixtures of the environment. Therefore, in this study the interaction treatment of municipal auto-battery leachate (MABL) and Elewi-Odo municipal auto-battery recycling-site leachate (EOMABRL), a popular agent for the activation of diabetes and hypertension with key enzymes linked to NIDDM (α-glucosidase and α-amylase and hypertension (Angiotensin 1-converting enzyme (ACE) were evaluated. Both types of leachates significantly (p<0.05) activated α-glucosidase, α-amylase and ACE activities in a dosedependent manner; however, the MABL were stronger activators of α-amylase and α-glucosidase than EOMABRL. Similarly, the MABL strongly activated Agiotensin 1-converting enzyme (Pro-hypertensive agent) than EOMABRL and significantly (p<0.05) increased malondiadehyde (MDA) production in the pancreas in dose-dependent manner. Therefore, increased activity of α-glucosidase, α-amylase, ACE and induction of lipid peroxidation in battery leachate treated-rat is the mechanism of toxicity through which they induce NIDDM and hypertension.
