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Fixed Drug Eruption (FDE) is a common cutaneous adverse drug reaction. It is characterized by recurrent lesion in the same anatomical area followed by drug rechallenge. Although NSAIDs are common agents that cause drug eruptions, piroxicam is rarely reported as the causative agent of FDE in Indonesia. Piroxicam is widely used in this region for various symptoms of joint pain. We report a piroxicam-induced FDE case in this article.