Managers and other stakeholders must take decisions, based on audited financial reports of organizations in such a way that wise choices are more likely to be taken. MIS and audit focuses on this need for sound information for decisiontaking. This study aims at finding out the relationship between Management Information System (MIS) and audit practice in Delta State, South-South zone of Nigeria. MIS and audit processes are targeted at satisfying the informational needs of financial statements end-users in primarily used in assessing the liquidity, profitability, and performance of an entity for a particular period of time. A survey design was adopted in this study. Seventeen (17) small-sized audit service firms located within Warri and Asaba metropolis of the State were used as sample. The entire population of this study was 70 and since they were accessible, the population was adopted as sample. A twelve-item structured questionnaire was raised to test each research question. The questionnaire, which was personally administered, was based on the likert 5-point scale of Strongly Agreed (SA), Agreed (A), Undecided (U), Strongly Disagreed (SD), and Disagreed (D) to which the subjects (accounting/audit professionals) were expected to respond. Simple percentage method was used in the analysis of data in response to the research questions; while the hypotheses were tested using the Pearson Moment Correlation Coefficient at 0.05 level of significance. The study showed that significant relationship exists between MIS and audit practice, on one side, and financial reporting of organizations, on the other side, for the enhancement of business intercourse and provision of more accurate, reliable and timeous financial information to a wide variety of users. Conclusion was drawn and the researchers recommended that there should be flexibility in the nature, pattern and structure of MIS in organizations so as to allow uninterrupted information flow; amongst others.