Biochemistry & Analytical Biochemistry

Abstract

Liver Dysfunction in TB-Diabetic and TB Non-Diabetic Patients Admitted in TB Referral Hospital in Western Cameroon

Sama LF, Ali IM, Noubom M, Nganou Djinou Ol, Wam EC, Bamou R, Kuiate J and Tume B. Christopher

Background: Liver Function Tests (LFTs) are group of tests that help in diagnosis, monitoring therapy, and assessing prognosis of liver disease. Methods: To estimate liver function tests in TB-DM and TB without diabetes, we conducted a cross-sectional study in sputum positive pulmonary TB patients in two TB management clinics in Bamenda and Bafoussam in the North West and West regions of Cameroon respectively from November 2014 to July 2015. Results: Of the 189 who patients who were recruited in the study 11.2% (21/189) were TB-DM, 65.1% (123/189) were TB without DM. The mean age of TB-DM was 41.38 ± 14.36 years with age found between 21 and 70 years whereas in TB without DM, the mean age was 35.76 ± 17.64 with minimum age being 12 years and maximum age 82 years. Of these participants, more than half presented abnormal liver function profile with 78.3% (148/189), 39.7% (75/189), 88.36% (167/189), and 91.54% (173/189) presenting abnormal levels of ALP, GGT, ALAT and ASAT respectively. High levels of liver enzymes were observe between the two types of population with no significant. Conclusion: This study showed high levels of liver enzymes in TB-diabetic and TB non-diabetic patients but no significant difference was observed between the two populations. Therefore, proper follow-up during TB treatment should be mandatory.