jdm

Journal of Diabetes & Metabolism

ISSN - 2155-6156

Abstract

Involvement of SIRT1 in Zn2+, Streptozotocin, Non-Obese Diabetic, and Cytokine-Mediated Toxicities of β-cells

Christian T. Sheline

Zn2+ toxicity is implicated in pancreatic β-cell death that occurs secondarily to: streptozotocin exposure in vitro and both autoimmune attack or streptozotocin in vivo models of T1DM.

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