Objective: The plot of this study is to obtain a grasp regarding the effect of different fluids (Gastric medium, simulated gastric fluid without enzyme, ORS solution, rice water, lentil soup, watermelon juice, apple juice, mango juice, pomegranate juice, black and green tea) on dissolution of metronidazole tablet by alteration of different medium.
Method: Our study had focused on the in vitro dissolution study of metronidazole in the presence of different fluids (Gastric medium, simulated gastric fluid without enzyme, ORS solution, rice water, lentil soup, watermelon juice, apple juice, mango juice, pomegranate juice, black and green tea) which has been commonly used in diarrheal condition to obtain quickest and profound dissolution for the metronidazole tablet. Different dissolution medium was prepared from 200 ml of fluids and 700 ml of 0.1 N HCl. pH was adjusted to pH 1.2. One commonly available marketed brand is used for the study. Dissolution study was performed as per mentioned in Indian pharmacopoeia. For the analysis of study, we used Graph Pad prism version 8 and Microsoft excel. ANOVA followed by Tukey's test was performed for the comparison of dissolution in different fluids
Result: The mean dissolution of metronidazole tablet in Rice water, Lentil soup, Watermelon juice, Mango juice, Pomegranate juice, Black tea and Green tea are significantly different from the dissolution on 0.1 N HCl medium (p<0.05, 95% CI).The dissolution in simulated gastric fluid without enzyme, ORS solution and apple juice are not significantly different from 0.1 N HCl medium (p>0.05, 95% CI).The highest percentage drug release of Metronidazole was found in apple juice (102.78 ± 2.10). In lentil soup dissolution of Metronidazole doesn’t complies with the IP specification (78.69 ± 1.89).
Conclusion: Metronidazole tablet plays a vital role in treatment of diarrhea but before it shows its therapeutic effect on body, it must have to dissolve first. So, dissolution is considered as an important parameter to determine the bioavailability of drug as well as its efficacy. Our study concludes that administration of apple juice can be beneficial on other hand lentil soup can decrease the therapeutic effect of metronidazole tablet.
Published Date: 2020-06-29; Received Date: 2020-05-28