Fatma Ghrairi, El Arem Amira, Chahed Henda, Lamia Lahouar, Lotfi Achour and Salem Said
The present study was carried out to investigate the possible antioxidant effects of raisin extract “Karkni” on biochemical parameters in alloxan-induced diabetic rats. Three doses of extract, 125, 250 and 375 mg/kg were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein LDL-cholesterol, creatinine, uric acid, total protein, glycosylated hemoglobin (HbA1c), Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) while high density lipoprotein HDL cholesterol, total hemoglobin and lactate dehydrogenase (LDH) levels were significantly decreased compared to normal rats (P<0.05). The changes of the above parameters to their normal levels after 4 weeks of treatment were observed mainly with the second dose 250 mg/kg. The overall results suggest that the “Karkni” extract possesses potential hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rats.
