Rapid medicine and pharmacy progress bring new high-technology medical product to controlling and treating different diseases. Unfortunately, it does not correct a problem of drugs adverse events (ADE) from mild side effects till severe hyper sensitivity reactions, which can lead a new diseases and forming a temporary or total disability and death in some cases. There are about 17 thousand of different medicines in the world now, nearly 90% of them where done in last ten years. According to update data in last ten years mortality rate due to ADE takes 4-6 places in the world. In various ways the rate of hospitalization due to ADE is from 2%, 4% to 12%. As well as, ADE increases the volume of direct and indirect cost of patient treatment. In USA treatment of patients with ADE is about 30, 1 milliard dollars per year. According to Sultana, treatment cost for one person with one ADE averages about 2262$. According to Wester et al. most often ADE are gastrointestinal bleeding, cerebrospinal bleeding, cardiovascular accidents, and other bleeding and renal disorders. Primary ADE rate among medicines belong to nonsteroidal antiinflammatory drug. According to meta-analysis prospective studies of Lazarou et al. as a result of ADE there were more than 100000 death cases. Makary determined that most commonly ADE was because of medical error.