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R-Spondin 1 Regulates WNT Signaling Pathway by Antagonizing the Function of Dickkopf Homolog 1 | Abstract
Single Cell Biology

Single Cell Biology
Open Access

ISSN: 2168-9431

PH: +447939540

Abstract

R-Spondin 1 Regulates WNT Signaling Pathway by Antagonizing the Function of Dickkopf Homolog 1

Yang Wang, Bingqiang Zhang and Wei Zou

The WNT family of secreted proteins play important roles in diverse biological processes, including development, proliferation, and differentiation, which regulate various diseases, such as prostate cancer, breast cancer, glioblastoma, type II diabetes and others. The WNT ligands could activate two major intracellular pathways: known as the canonical pathway which is β-catenin-dependent, and non-canonical pathway which is β-catenin-independent.

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